| Safecracker: The Ultimate Puzzle Adventure Game Details | Screens | JoWood | | |
| Saint Game Details | Screens | UFO | | |
| Sakura Wars: So Long, My Love Game Details | Review | Screens | NIS America | 9/10 | |
| Sam & Max: Beyond Time and Space Game Details | Screens | Atari | | |
| Sam and Max: Season One Game Details | Review | Screens | The Adventure Company | 7/10 | |
| Samba de Amigo Game Details | Screens | SEGA | | |
| Samurai Warriors 3 Game Details | Review | Screens | Nintendo | 5/10 | |
| Samurai Warriors Katana Game Details | Review | Screens | Koei | 6/10 | |
| Sandy Beach Game Details | Screens | Konami | | |
| Scarface: The World is Yours Game Details | Review | Screens | Vivendi | 8/10 | |
| Scene It? Bright Lights! Big Screen! Game Details | Screens | Warner Bros. | | |
| Scene It? Twilight Game Details | Screens | Konami | | |
| Scooby-Doo! and the Spooky Swamp Game Details | Screens | Warner Bros. | | |
| SCORE International Baja 1000: World Championship Off Road Racing Game Details | Screens | Activision | | |
| Secret Files 2: Puritas Cordis Game Details | Screens | Koch | | |
| Secret Files Tunguska Game Details | Screens | Deep Silver | | |
| SEGA Bass Fishing Game Details | Review | Screens | SEGA | 6/10 | |
| SEGA Superstars Tennis Game Details | Review | Screens | SEGA | 8/10 | |
| Sengoku Basara 2 Heroes Game Details | Screens | Capcom | | |
| Sengoku Basara: Samurai Heroes Game Details | Review | Screens | Capcom | 7/10 | |
| Sesame Street: Elmo's Musical Monsterpiece Game Details | Screens | Warner Bros. | | |
| Shaun White Skateboarding Game Details | Preview | Screens | Ubisoft | | |
| Shaun White Snowboarding: World Stage Game Details | Screens | Ubisoft | | |
| Sherlock Holmes: Mystery of the Mummy Game Details | Screens | Frogwares | | |
| Sherlock Holmes: The Silver Earring Game Details | Screens | Dreamcatcher | | |
| Shin-Chan Las nuevas aventuras para Wii! Game Details | Screens | 505 | | |
| Shiren the Wanderer Game Details | Screens | Atlus | | |
| Showtime Championship Boxing Game Details | Screens | Zoo Digital | | |
| Shrek the Third Game Details | Screens | Activision | | |
| Sid Meier's Pirates! Game Details | Review | Screens | 2K | 5/10 | |
| Silent Hill: Shattered Memories Game Details | Review | Screens | Konami | 9/10 | |
| Sim Animals Game Details | Screens | EA | | |
| SimAnimals Africa Game Details | Review | Screens | EA | 4/10 | |
| SimCity Creator Game Details | Screens | EA | | |
| Sin and Punishment: Successor of the Skies Game Details | Review | Preview | Screens | Nintendo | 10/10 | |
| Skylanders Swap Force Game Details | Screens | Activision Blizzard | | |
| Skylanders: Spyro's Adventure Game Details | Preview | Screens | Activision | | |
| Skyscraper Game Details | Screens | Midas | | |
| Smarty Pants Game Details | Review | Screens | EA | 7/10 | |
| SNK Arcade Classics Vol. 1 Game Details | Review | Screens | Ignition | 7/10 | |
| Soccer Bashi Game Details | Review | Screens | Icon | 4/10 | |
| Sonic & SEGA All-Stars Racing Game Details | Review | Screens | SEGA | 7/10 | |
| Sonic and the Black Knight Game Details | Review | Screens | SEGA | 6/10 | |
| Sonic and the Secret Rings Game Details | Review | Screens | SEGA | 8/10 | |
| Sonic Colours Game Details | Review | Screens | SEGA | 8/10 | |
| Sonic Riders: Zero Gravity Game Details | Review | Screens | SEGA | 6/10 | |
| Sonic the Hedgehog 4: Episode I Game Details | Review | Screens | SEGA | 7/10 | |
| Sonic Unleashed Game Details | Review | Screens | SEGA | 6/10 | |
| Sorcery Blade Game Details | Screens | Kemco | | |
| Soul Eater: Monotone Princess Game Details | Screens | Square Enix | | |
| SoulCalibur Legends Game Details | Screens | Ubisoft | | |
| Space Chimps Game Details | Screens | Brash | | |
| Space Invaders Get Even Game Details | Screens | Square Enix | | |
| Spectrobes: Origins Game Details | Screens | Disney | | |
| Speed Racer: The Videogame Game Details | Screens | Warner Bros. | | |
| Spider-Man 3 Game Details | Review | Screens | Activision | 4/10 | |
| Spider-Man: Edge of Time Game Details | Screens | Activision | | |
| Spider-Man: Friend or Foe Game Details | Review | Screens | Activision | 6/10 | |
| Spider-Man: Shattered Dimensions Game Details | Preview | Screens | Activision | | |
| SPOGS Racing Game Details | Screens | D2C | | |
| Spongebob Squarepants: Creature From The Krusty Krab Game Details | Screens | THQ | | |
| SpongeBob Squigglepants Game Details | Screens | THQ | | |
| Spore Hero Game Details | Review | Preview | Screens | EA | 5/10 | |
| Sports Island Game Details | Screens | Hudson | | |
| Sports Island 2 Game Details | Screens | Hudson | | |
| Sports Island 3 Game Details | Screens | Hudson | | |
| Spot the Differences! Game Details | Screens | Sanuk | | |
| SPRay Game Details | Screens | Tecmo | | |
| Spyborgs Game Details | Screens | Capcom | | |
| SSX Blur Game Details | Review | Screens | EA Sports | 8/10 | |
| Star Soldier R Game Details | Review | Screens | Hudson | 8/10 | |
| Star Trek: Conquest Game Details | Screens | Bethesda | | |
| Star Wars The Clone Wars: Republic Heroes Game Details | Screens | LucasArts | | |
| Star Wars: The Clone Wars - Lightsaber Duels Game Details | Preview | Screens | LucasArts | | |
| Star Wars: The Force Unleashed Game Details | Screens | LucasArts | | |
| Star Wars: The Force Unleashed II Game Details | Preview | Screens | LucasArts | | |
| Stop Stress: A Day of Fury Game Details | Review | Screens | Abylight | 4/10 | |
| Strong Bad Game Details | Review | Screens | Telltale | 8/10 | |
| Strong Bad Episode 2: Strong Badia the Free Game Details | Review | Screens | Telltale | 9/10 | |
| Strong Bad Episode 3: Baddest of the Bands Game Details | Review | Screens | Telltale | 7/10 | |
| Strong Bad Episode 4: Dangeresque 3 Game Details | Review | Screens | Telltale | 8/10 | |
| Strong Bad Episode 5: 8-Bit is Enough Game Details | Review | Screens | Telltale | 9/10 | |
| Stunt Cars Game Details | Screens | Icon | | |
| Summer Challenge Athletics Tournament Game Details | Review | Screens | pQube | 5/10 | |
| Super Fruit Fall Game Details | Screens | System 3 | | |
| Super Mario All-Stars: 25th Anniversary Edition Game Details | Screens | Nintendo | | |
| Super Mario Galaxy Game Details | Review | Preview | Screens | Nintendo | 10/10 | |
| Super Mario Galaxy 2 Game Details | Review | Preview | Screens | Nintendo | 10/10 | |
| Super Monkey Ball: Banana Blitz Game Details | Review | Preview | Screens | SEGA | 5/10 | |
| Super Monkey Ball: Step & Roll Game Details | Review | Screens | SEGA | 6/10 | |
| Super Paper Mario Game Details | Review | Preview | Screens | Nintendo | 7/10 | |
| Super Smash Bros. Brawl Game Details | Review | Preview | Screens | Nintendo | 9/10 | |
| Super Swing Golf Game Details | Review | Screens | Rising Star | 7/10 | |
| Supersonic Racer Game Details | Screens | Funbox | | |
| Surf's Up Game Details | Screens | Ubisoft | | |
| Swords Game Details | Screens | Majesco | | |
| Swords & Soldiers Game Details | Review | Screens | Ronimo | 8/10 | |